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Figuring out the system of motion (MOA) of novel or Normally transpiring compounds typically relies on assays customized for unique target proteins. In this article we explore an alternate approach depending on pattern matching reaction profiles acquired utilizing cultured neuronal networks. Conolidine and cannabidiol are plant-derivatives with rec
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A fresh review demonstrates that the compound conolidine, found in the pinwheel flower, only binds to at least one unique scavenger receptor."We verified that conolidine binds towards the newly discovered opioid receptor ACKR3, when showing no affinity for the other 4 classical opioid receptors. By doing this, conolidine blocks ACKR3 and prevents i